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Target
Nociceptin receptor
Ligand
BDBM239937
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
230±n/a nM
Comments
extracted
Citation
 Nolte, B; Schröder, W; Linz, K; Englberger, W; Schick, H; Graubaum, H; Braun, B; Ozegowski, S; Bálint, J; Sonnenschein, H Substituted 4-aminocyclohexane derivatives US Patent  US9403767 Publication Date 8/2/2016 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM239937
Synonyms:
US9403767, 121 | US9403767, 123
Type:
Small organic molecule
Emp. Form.:
C25H35N3O
Mol. Mass.:
393.5649
SMILES:
CN(C)C(=O)CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1 |(9.96,-5.07,;8.62,-4.3,;8.62,-2.76,;7.29,-5.07,;7.29,-6.61,;5.95,-4.3,;4.62,-5.07,;5.53,-6.31,;3.29,-4.3,;4.01,-2.94,;3.19,-1.63,;1.66,-1.69,;.93,-3.05,;1.75,-4.35,;.19,-1.21,;-.95,-2.24,;-.13,.3,;1.87,-.16,;.66,.79,;.87,2.31,;2.3,2.89,;3.51,1.94,;3.3,.42,;3.39,-5.83,;4.78,-6.51,;4.89,-8.05,;3.61,-8.91,;2.23,-8.23,;2.12,-6.7,)|
Structure:
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