Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM239942
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
930±n/a nM
Comments
extracted
Citation
 Nolte, B; Schröder, W; Linz, K; Englberger, W; Schick, H; Graubaum, H; Braun, B; Ozegowski, S; Bálint, J; Sonnenschein, H Substituted 4-aminocyclohexane derivatives US Patent  US9403767 Publication Date 8/2/2016 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM239942
Synonyms:
US9403767, 128
Type:
Small organic molecule
Emp. Form.:
C28H39N7
Mol. Mass.:
473.6562
SMILES:
CN(C)c1nc(nc(n1)N(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1)N(C)C |(-5.04,-10.7,;-5.86,-9.4,;-7.4,-9.45,;-5.13,-8.04,;-5.95,-6.73,;-5.23,-5.37,;-3.69,-5.32,;-2.87,-6.62,;-3.6,-7.98,;-1.33,-6.57,;-1.44,-8.11,;-.61,-5.21,;.72,-4.44,;.72,-2.9,;-.61,-2.13,;-1.94,-2.9,;-1.94,-4.44,;-1.33,-.77,;-2.87,-.72,;-1.44,.77,;.11,-.77,;-.7,.54,;.02,1.9,;1.56,1.95,;2.37,.64,;1.65,-.72,;.11,-6.57,;1.65,-6.62,;2.37,-7.98,;1.56,-9.29,;.02,-9.24,;-.7,-7.88,;-6.04,-4.07,;-5.32,-2.71,;-7.58,-4.12,)|
Structure:
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