Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM239858
Substrate
n/a
Meas. Tech.
Binding Assay
Temperature
298.15±n/a K
Ki
49±n/a nM
Comments
extracted
Citation
 Nolte, B; Schröder, W; Linz, K; Englberger, W; Schick, H; Graubaum, H; Braun, B; Ozegowski, S; Bálint, J; Sonnenschein, H Substituted 4-aminocyclohexane derivatives US Patent  US9403767 Publication Date 8/2/2016 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM239858
Synonyms:
US9403767, 6
Type:
Small organic molecule
Emp. Form.:
C28H36N4
Mol. Mass.:
428.6122
SMILES:
CN(C)C1(CCC(CC1)(N1CCCC1)C(=N)c1cc2ccccc2n1C)c1ccccc1 |(1.92,-6.67,;.39,-6.88,;.77,-8.38,;-.55,-5.67,;-2,-5.14,;-2.27,-3.63,;-1.09,-2.64,;.36,-3.16,;.62,-4.68,;-2.27,-1.65,;-3.76,-2.02,;-4.58,-.71,;-3.59,.47,;-2.16,-.11,;-.32,-1.3,;-1.09,.03,;1.22,-1.3,;2.13,-2.55,;3.59,-2.07,;4.92,-2.84,;6.26,-2.07,;6.26,-.53,;4.92,.24,;3.59,-.53,;2.13,-.06,;1.65,1.41,;-1.03,-7.13,;-0,-8.28,;-.48,-9.74,;-1.98,-10.06,;-3.01,-8.92,;-2.54,-7.45,)|
Structure:
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