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Target
Mu-type opioid receptor
Ligand
BDBM239945
Substrate
n/a
Meas. Tech.
Binding Assay
Temperature
298.15±n/a K
Ki
1580±n/a nM
Comments
extracted
Citation
 Nolte, B; Schröder, W; Linz, K; Englberger, W; Schick, H; Graubaum, H; Braun, B; Ozegowski, S; Bálint, J; Sonnenschein, H Substituted 4-aminocyclohexane derivatives US Patent  US9403767 Publication Date 8/2/2016 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM239945
Synonyms:
US9403767, 132
Type:
Small organic molecule
Emp. Form.:
C27H34FN3
Mol. Mass.:
419.5774
SMILES:
CN(C)C1(CCC(CC1)(N1CCCC1)c1[nH]c2ccc(F)cc2c1C)c1ccccc1 |(-3.23,2.8,;-3.9,1.42,;-5.21,2.24,;-3.04,.14,;-2.99,-1.4,;-1.63,-2.12,;-.32,-1.3,;-.37,.24,;-1.73,.96,;.1,-2.78,;1.55,-3.31,;1.5,-4.85,;.02,-5.27,;-.84,-4,;1.22,-1.3,;2.13,-2.55,;3.59,-2.07,;4.92,-2.84,;6.26,-2.07,;6.26,-.53,;7.59,.24,;4.92,.24,;3.59,-.53,;2.13,-.06,;1.65,1.41,;-4.58,.14,;-5.35,-1.19,;-6.89,-1.19,;-7.66,.14,;-6.89,1.48,;-5.35,1.48,)|
Structure:
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