Target
Orexin receptor type 2
Ligand
BDBM240124
Substrate
n/a
Meas. Tech.
Intracellular Calcium Assay
Temperature
310.15±n/a K
IC50
4±n/a nM
Comments
extracted
Citation
 Bolli, MBoss, CBrotschi, CHeidmann, BSifferlen, TWilliams, JT Azetidine amide derivatives as orexin receptor antagonists US Patent  US9403813 Publication Date 8/2/2016 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM240124
Synonyms:
US9403813, 29
Type:
Small organic molecule
Emp. Form.:
C23H21FN6O3
Mol. Mass.:
448.4496
SMILES:
COc1cc(C(=O)N2CC[C@H]2c2nc(no2)-c2cccc(F)c2C)c(cc1C)-n1nccn1
Structure:
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