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Target
Mitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085]
Ligand
BDBM162212
Substrate
n/a
Meas. Tech.
Bub1 Kinase Assay
pH
8±n/a
IC50
>20000±n/a nM
Comments
extracted
Citation
 Bärfacker, L; Prechtl, S; Siemeister, G; Wengner, AM; Ackerstaff, J; Nowak-Reppel, K; Bader, B; Lienau, P; Stöckigt, D; Heinrich, T Amino-substituted isothiazoles US Patent  US9682995 Publication Date 6/20/2017 
Target
Name:
Mitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085]
Synonyms:
BUB1 | BUB1L | BUB1_HUMAN | Mitotic checkpoint serine/threonine-protein kinase BUB1 (aa 704-1085)
Type:
n/a
Mol. Mass.:
43624.72
Organism:
Homo sapiens (Human)
Description:
O43683[704-1085]
Residue:
382
Sequence:
DAAIAEDPPDAIAGLQAEWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLECKRSRK
  
Inhibitor
Name:
BDBM162212
Synonyms:
US9682995, 109
Type:
Small organic molecule
Emp. Form.:
C18H16F2N6O2S
Mol. Mass.:
418.42
SMILES:
CN(C)C(=O)c1cnc(Nc2snc(C)c2C(=O)Nc2ccc(F)c(F)c2)cn1
Structure:
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