Reaction Details Report a problem with these data
Target
Trace amine-associated receptor 1
Ligand
BDBM240666
Substrate
n/a
Meas. Tech.
Radioligand Binding (rat TAAR1)
pH
7.4±n/a
Ki
26.8±n/a nM
Comments
extracted
Citation
 Galley, G; Ghellamallah, C; Norcross, R; Pflieger, P Triazole carboxamides and uses thereof US Patent  US9416127 Publication Date 8/16/2016 
Target
Name:
Trace amine-associated receptor 1
Synonyms:
TAAR1_RAT | Ta1 | Taar1 | Tar1 | Trace amine receptor 1 (TARR1) | Trace amine-associated receptor 1 | Trace amine-associated receptor 1 (TAAR1) | Trace amine-associated receptor1 | Trar1
Type:
Enzyme
Mol. Mass.:
38034.73
Organism:
Rattus norvegicus (Rat)
Description:
Q923Y9
Residue:
332
Sequence:
MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
  
Inhibitor
Name:
BDBM240666
Synonyms:
US9416127, 16 | US9416127, 3
Type:
Small organic molecule
Emp. Form.:
C20H19F2N5O3
Mol. Mass.:
415.3934
SMILES:
FC(F)Oc1ccc(cc1)-n1ncc(n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Structure:
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