Reaction Details Report a problem with these data
Target
Polyphenol oxidase 1
Ligand
BDBM240723
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
6.8±n/a
IC50
90±n/a nM
Comments
extracted
Citation
 Poigny, S; Belaubre, F Heterocyclic resorcinol derivatives, preparation of same and cosmetic uses thereof US Patent  US9422261 Publication Date 8/23/2016 
Target
Name:
Polyphenol oxidase 1
Synonyms:
PPO1 | PPO1_AGABI | Polyphenol oxidase | Tyrosinase
Type:
Enzyme
Mol. Mass.:
63902.83
Organism:
Agaricus bisporus (White button mushroom)
Description:
Q00024
Residue:
568
Sequence:
MSHLLVSPLGGGVQPRLEINNFVKNDRQFSLYVQALDRMYATPQNETASYFQVAGVHGYPLIPFDDAVGPTEFSPFDQWTGYCTHGSTLFPTWHRPYVLILEQILSGHAQQIADTYTVNKSEWKKAATEFRHPYWDWASNSVPPPEVISLPKVTITTPNGQKTSVANPLMRYTFNSVNDGGFYGPYNQWDTTLRQPDSTGVNAKDNVNRLKSVLKNAQASLTRATYDMFNRVTTWPHFSSHTPASGGSTSNSIEAIHDNIHVLVGGNGHMSDPSVAPFDPIFFLHHANVDRLIALWSAIRYDVWTSPGDAQFGTYTLRYKQSVDESTDLAPWWKTQNEYWKSNELRSTESLGYTYPEFVGLDMYNKDAVNKTISRKVAQLYGPQRGGQRSLVEDLSNSHARRSQRPAKRSRLGQLLKGLFSDWSAQIKFNRHEVGQSFSVCLFLGNVPEDPREWLVSPNLVGARHAFVRSVKTDHVAEEIGFIPINQWIAEHTGLPSFAVDLVKPLLAQGLQWRVLLADGTPAELDSLEVTILEVPSELTDDEPNPRSRPPRYHKDITHGKRGGCREA
  
Inhibitor
Name:
BDBM240723
Synonyms:
US9422261, Compound 1
Type:
Small organic molecule
Emp. Form.:
C12H12O2S
Mol. Mass.:
220.287
SMILES:
CC(c1cccs1)c1ccc(O)cc1O
Structure:
Search PDB for entries with ligand similarity: