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Target
Polyphenol oxidase 1
Ligand
BDBM240728
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
6.8±n/a
IC50
90000±n/a nM
Comments
extracted
Citation
 Poigny, S; Belaubre, F Heterocyclic resorcinol derivatives, preparation of same and cosmetic uses thereof US Patent  US9422261 Publication Date 8/23/2016 
Target
Name:
Polyphenol oxidase 1
Synonyms:
PPO1 | PPO1_AGABI | Polyphenol oxidase | Tyrosinase
Type:
Enzyme
Mol. Mass.:
63902.83
Organism:
Agaricus bisporus (White button mushroom)
Description:
Q00024
Residue:
568
Sequence:
MSHLLVSPLGGGVQPRLEINNFVKNDRQFSLYVQALDRMYATPQNETASYFQVAGVHGYPLIPFDDAVGPTEFSPFDQWTGYCTHGSTLFPTWHRPYVLILEQILSGHAQQIADTYTVNKSEWKKAATEFRHPYWDWASNSVPPPEVISLPKVTITTPNGQKTSVANPLMRYTFNSVNDGGFYGPYNQWDTTLRQPDSTGVNAKDNVNRLKSVLKNAQASLTRATYDMFNRVTTWPHFSSHTPASGGSTSNSIEAIHDNIHVLVGGNGHMSDPSVAPFDPIFFLHHANVDRLIALWSAIRYDVWTSPGDAQFGTYTLRYKQSVDESTDLAPWWKTQNEYWKSNELRSTESLGYTYPEFVGLDMYNKDAVNKTISRKVAQLYGPQRGGQRSLVEDLSNSHARRSQRPAKRSRLGQLLKGLFSDWSAQIKFNRHEVGQSFSVCLFLGNVPEDPREWLVSPNLVGARHAFVRSVKTDHVAEEIGFIPINQWIAEHTGLPSFAVDLVKPLLAQGLQWRVLLADGTPAELDSLEVTILEVPSELTDDEPNPRSRPPRYHKDITHGKRGGCREA
  
Inhibitor
Name:
BDBM240728
Synonyms:
US9422261, Arbutin
Type:
Small organic molecule
Emp. Form.:
C12H16O7
Mol. Mass.:
272.2512
SMILES:
OCC1O[C@@H](Oc2ccc(O)cc2)C(O)[C@@H](O)[C@@H]1O |r|
Structure:
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