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Target
Eukaryotic elongation factor 2 kinase
Ligand
BDBM293929
Substrate
n/a
Meas. Tech.
Kinase-Glo luminescent kinase assay
IC50
10000000±n/a nM
Citation
 Dodd, JH Compounds inhibiting eukaryotic elongation factor 2 kinase activity US Patent  US10106552 Publication Date 10/23/2018 
Target
Name:
Eukaryotic elongation factor 2 kinase
Synonyms:
Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase | EEF2K | EF2K_HUMAN | Eukaryotic elongation factor 2 kinase (EEF2K) | Eukaryotic elongation factor 2 kinase (eEF-2K) | Serine/threonine-protein kinase EEF2K | eEF-2 kinase | eEF-2K
Type:
Protein
Mol. Mass.:
82116.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
725
Sequence:
MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYYSNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAVTGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSPQVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFSDLDNMASRDHDHLDNHRESENSGDSGYPSEKRGELDDPEPREHGHSYSNRKYESDEDSLGSSGRVCVEKWNLLNSSRLHLPRASAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEGGRFCEKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRQSMILVARAFDSGQNLSPDRCQDWLEALHWYNTALEMTDCDEGGEYDGMQDEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAWAQMEE
  
Inhibitor
Name:
BDBM293929
Synonyms:
US10106552, Compound 4
Type:
Small organic molecule
Emp. Form.:
C22H18ClN3O2S
Mol. Mass.:
423.915
SMILES:
NC(=O)c1sc2nc3CCC(Cc3c(-c3ccc(Cl)o3)c2c1N)c1ccccc1
Structure:
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