Reaction Details Report a problem with these data
Target
Glutaredoxin-1
Ligand
BDBM240789
Substrate
n/a
Meas. Tech.
GRX Assay
pH
8±0
Temperature
298.15±0 K
Ki
9.13e+4±n/a nM
Citation
 Sadhu, SS; Callegari, E; Zhao, Y; Guan, X; Seefeldt, T Evaluation of a dithiocarbamate derivative as an inhibitor of human glutaredoxin-1. J Enzyme Inhib Med Chem 28:456-62 (2013) [PubMed]  Article 
Target
Name:
Glutaredoxin-1
Synonyms:
GLRX | GLRX1_HUMAN | GRX | Glutaredoxin-1 (GRX-1)
Type:
Protein
Mol. Mass.:
11778.14
Organism:
Homo sapiens (Human)
Description:
P35754
Residue:
106
Sequence:
MAQEFVNCKIQPGKVVVFIKPTCPYCRRAQEILSQLPIKQGLLEFVDITATNHTNEIQDYLQQLTGARTVPRVFIGKDCIGGCSDLVSLQQSGELLTRLKQIGALQ
  
Inhibitor
Name:
BDBM240789
Synonyms:
2-AAPA
Type:
Small organic molecule
Emp. Form.:
C18H22N4O6S4
Mol. Mass.:
518.65
SMILES:
CC(=O)NC(CSC(=S)Nc1ccc(NC(=S)SCC(NC(C)=O)C(O)=O)cc1)C(O)=O
Structure:
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