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Target
Aminopeptidase N
Ligand
BDBM240830
Substrate
n/a
Meas. Tech.
APN Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
172870±1990 nM
Comments
extracted
Citation
 Zhang, X; Zhang, L; Zhang, J; Feng, J; Yuan, Y; Fang, H; Xu, W Design, synthesis and preliminary activity evaluation of novel 3-amino-2-hydroxyl-3-phenylpropanoic acid derivatives as aminopeptidase N/CD13 inhibitors. J Enzyme Inhib Med Chem 28:545-51 (2013) [PubMed]  Article 
Target
Name:
Aminopeptidase N
Synonyms:
AMPN_PIG | ANPEP | AP-M | AP-N | Alanyl aminopeptidase | Aminopeptidase M | Aminopeptidase N (APN) | CD_antigen=CD13 | Microsomal aminopeptidase | gp130 | pAPN
Type:
Protein
Mol. Mass.:
108810.25
Organism:
Sus scrofa (Pig)
Description:
P15145
Residue:
963
Sequence:
MAKGFYISKALGILGILLGVAAVATIIALSVVYAQEKNKNAEHVPQAPTSPTITTTAAITLDQSKPWNRYRLPTTLLPDSYNVTLRPYLTPNADGLYIFKGKSIVRLLCQEPTDVIIIHSKKLNYTTQGHMVVLRGVGDSQVPEIDRTELVELTEYLVVHLKGSLQPGHMYEMESEFQGELADDLAGFYRSEYMEGNVKKVLATTQMQSTDARKSFPCFDEPAMKATFNITLIHPNNLTALSNMPPKGSSTPLAEDPNWSVTEFETTPVMSTYLLAYIVSEFQSVNETAQNGVLIRIWARPNAIAEGHGMYALNVTGPILNFFANHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRENALLFDPQSSSISNKERVVTVIAHELAHQWFGNLVTLAWWNDLWLNEGFASYVEYLGADHAEPTWNLKDLIVPGDVYRVMAVDALASSHPLTTPAEEVNTPAQISEMFDSISYSKGASVIRMLSNFLTEDLFKEGLASYLHAFAYQNTTYLDLWEHLQKAVDAQTSIRLPDTVRAIMDRWTLQMGFPVITVDTKTGNISQKHFLLDSESNVTRSSAFDYLWIVPISSIKNGVMQDHYWLRDVSQAQNDLFKTASDDWVLLNVNVTGYFQVNYDEDNWRMIQHQLQTNLSVIPVINRAQVIYDSFNLATAHMVPVTLALDNTLFLNGEKEYMPWQAALSSLSYFSLMFDRSEVYGPMKKYLRKQVEPLFQHFETLTKNWTERPENLMDQYSEINAISTACSNGLPQCENLAKTLFDQWMSDPENNPIHPNLRSTIYCNAIAQGGQDQWDFAWGQLQQAQLVNEADKLRSALACSNEVWLLNRYLGYTLNPDLIRKQDATSTINSIASNVIGQPLAWDFVQSNWKKLFQDYGGGSFSFSNLIQGVTRRFSSEFELQQLEQFKKNNMDVGFGSGTRALEQALEKTKANIKWVKENKEVVLNWFIEHS
  
Inhibitor
Name:
BDBM240830
Synonyms:
(2R,3S)-3-amino-2-hydroxy-N-((S)-1-(hydroxyamino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-3-phenylpropanamide hydrochloride (7g)
Type:
Small organic molecule
Emp. Form.:
C18H21N3O5
Mol. Mass.:
359.3764
SMILES:
N[C@H]([C@@H](O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NO)c1ccccc1 |r|
Structure:
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