Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM293993
Substrate
n/a
Meas. Tech.
In Vitro Assay GPR40 Calcium Flux Assay
Temperature
298.15±n/a K
EC50
37.0±n/a nM
Comments
extracted
Citation
 Meegalla, S; Player, MR; Huang, H; Winters, MP Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes US Patent  US10106553 Publication Date 10/23/2018 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM293993
Synonyms:
(2S)-5-(5-((4-(1-(1H-Tetrazol-5- yl)pent-3-yn-2- yl)phenoxy)methyl)benzo[b] thiophen-3-yl)-4-methylpyrimidine | US10106553, Compound 25
Type:
Small organic molecule
Emp. Form.:
C26H22N6OS
Mol. Mass.:
466.557
SMILES:
CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cncnc4C)c3c2)cc1 |r|
Structure:
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