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Target
Genome polyprotein [2420-3010]
Ligand
BDBM240863
Substrate
n/a
Meas. Tech.
HCV Replicon Assay
pH
7.5±n/a
Temperature
300.15±n/a K
EC50
4420±n/a nM
Comments
extracted
Citation
 Du, J; Sofia, MJ 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections US Patent  US9394331 Publication Date 7/19/2016 
Target
Name:
Genome polyprotein [2420-3010]
Synonyms:
POLG_HCVCO | RNA polymerase (NS5B) | RNA-directed RNA polymerase (NS5B)
Type:
Enzyme
Mol. Mass.:
65783.36
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
aa 2420-3010
Residue:
591
Sequence:
SMSYTWTGALITPCAAEETKLPINALSNSLLRHHNLVYATTSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSARSKFGYGAKDVRNLSSKAVNHIRSVWKDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPGQRVEFLVNAWKAKKCPMGFAYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAAAACRAAKLQDCTMLVCGDDLVVICESAGTQEDEASLRAFTEAMTRYSAPPGDPPKPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIQRLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVRTKLKLTPIPAASQLDLSSWFVAGYSGGDIYHSLSRARPRWFMWCLLLLSVGVGIYLLPNR
  
Inhibitor
Name:
BDBM240863
Synonyms:
US9394331, 125
Type:
Small organic molecule
Emp. Form.:
C26H35N6O9P
Mol. Mass.:
606.5647
SMILES:
COc1nc(N)nc2n(cnc12)C1O[C@H](COP(=O)(N[C@@H](C)C(=O)OCC(C)C)Oc2ccccc2)[C@@H](O)[C@]11CCO1 |r|
Structure:
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