Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase XIAP [124-240]
Ligand
BDBM240887
Substrate
n/a
Meas. Tech.
TR-FRET Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
2.98±n/a nM
Comments
extracted
Citation
 Mischke, SG Dimeric compounds US Patent  US9409888 Publication Date 8/9/2016 
Target
Name:
E3 ubiquitin-protein ligase XIAP [124-240]
Synonyms:
API3 | BIRC4 | Baculoviral IAP repeat-containing protein 2 (BIR2) | E3 ubiquitin-protein ligase XIAP (BIR2) | E3 ubiquitin-protein ligase XIAP BIR2 | IAP3 | XIAP | XIAP protein BIR2 | XIAP_HUMAN
Type:
Protein
Mol. Mass.:
13562.46
Organism:
Artificial Sequence
Description:
TR-FRET peptide Corresponds to amino acids 124-240 of human XIAP.
Residue:
117
Sequence:
RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE
  
Inhibitor
Name:
BDBM240887
Synonyms:
US9409888, 5
Type:
Small organic molecule
Emp. Form.:
C53H66BrN9O8
Mol. Mass.:
1037.051
SMILES:
CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1C[C@H](C[C@H]1C(=O)NC(C)C)NC(=O)c1ccc(cc1)C(=O)N1C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc12
Structure:
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