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Target
P2X purinoceptor 7
Ligand
BDBM241779
Substrate
n/a
Meas. Tech.
YO-PRO Assay
Temperature
310.15±n/a K
IC50
1.3±n/a nM
Comments
extracted
Citation
 Hilpert, K; Hubler, F; Kimmerlin, T; Renneberg, D; Stamm, S Heterocyclic amide derivatives as P2X7 receptor antagonists US Patent  US9409917 Publication Date 8/9/2016 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Homo sapiens (Human)
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM241779
Synonyms:
US9409917, 104 | US9409917, 105 | US9409917, 76 | US9409917, 77 | US9409917, 85 | US9409917, 86
Type:
Small organic molecule
Emp. Form.:
C17H14Cl2N2O2
Mol. Mass.:
349.211
SMILES:
Clc1cc2CCC(NC(=O)C3COc4ncccc34)c2c(Cl)c1
Structure:
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