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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50379220
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.5±n/a
Temperature
303.15±n/a K
IC50
55000±n/a nM
Comments
extracted
Citation
 Burnet, MW; Thaher, BA; Ehlert, J; Kubbutat, M; Schaechtele, C; Totzke, F Kinase modulators for the treatment of cancer US Patent  US9416123 Publication Date 8/16/2016 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50379220
Synonyms:
CHEMBL2011302 | US9416123, 16
Type:
Small organic molecule
Emp. Form.:
C15H9Cl3N4O2
Mol. Mass.:
383.617
SMILES:
Nc1c(C(O)=O)c(nn1-c1c(Cl)cc(Cl)cc1Cl)-c1ccncc1 |(13.17,-1.44,;12.69,.03,;11.23,.5,;9.89,-.27,;8.56,.5,;9.89,-1.81,;11.23,2.04,;12.69,2.52,;13.6,1.27,;15.14,1.27,;15.91,2.6,;15.13,3.93,;17.44,2.6,;18.22,1.26,;19.76,1.27,;17.45,-.07,;15.91,-.07,;15.14,-1.4,;9.98,2.95,;9.97,4.49,;8.62,5.24,;7.3,4.45,;7.32,2.9,;8.67,2.16,)|
Structure:
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