Reaction Details Report a problem with these data
Target
Genome polyprotein [1973-2420]
Ligand
BDBM241832
Substrate
n/a
Meas. Tech.
Luciferase Assay
EC50
0.068±n/a nM
Citation
 Zhang, J; Zhang, Y; Xie, H; Ren, Q; Hu, B; Fu, C; Wu, X; Li, S; Wang, C; Zhang, Z Spiro ring compound as hepatitis C virus (HCV) inhibitor and uses thereof US Patent  US9416139 Publication Date 8/16/2016 
Target
Name:
Genome polyprotein [1973-2420]
Synonyms:
Non-structural protein 5A (NS5A) | POLG_HCV1
Type:
Enzyme
Mol. Mass.:
48946.19
Organism:
Hepatitis C virus genotype 1a (HCV)
Description:
aa 1973-2420
Residue:
448
Sequence:
SGSWLRDIWDWICEVLSDFKTWLKAKLMPQLPGIPFVSCQRGYKGVWRVDGIMHTRCHCGAEITGHVKNGTMRIVGPRTCRNMWSGTFPINAYTTGPCTPLPAPNYTFALWRVSAEEYVEIRQVGDFHYVTGMTTDNLKCPCQVPSPEFFTELDGVRLHRFAPPCKPLLREEVSFRVGLHEYPVGSQLPCEPEPDVAVLTSMLTDPSHITAEAAGRRLARGSPPSVASSSASQLSAPSLKATCTANHDSPDAELIEANLLWRQEMGGNITRVESENKVVILDSFDPLVAEEDEREISVPAEILRKSRRFAQALPVWARPDYNPPLVETWKKPDYEPPVVHGCPLPPPKSPPVPPPRKKRTVVLTESTLSTALAELATRSFGSSSTSGITGDNTTTSSEPAPSGCPPDSDAESYSSMPPLEGEPGDPDLSDGSWSTVSSEANAEDVVCC
  
Inhibitor
Name:
BDBM241832
Synonyms:
US9416139, 10 | US9416139, 11
Type:
Small organic molecule
Emp. Form.:
C54H65N9O7
Mol. Mass.:
952.15
SMILES:
COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc(cc1)-c1ccc(c2CC3(Cc12)CCN(C)CC3)-c1ccc2nc([nH]c(=O)c2c1)[C@@H]1CC2CC2N1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Structure:
Search PDB for entries with ligand similarity: