Target
Genome polyprotein [1973-2419]
Ligand
BDBM241853
Substrate
n/a
Meas. Tech.
Luciferase Assay
EC50
0.539±n/a nM
Citation
 Zhang, JZhang, YXie, HRen, QHu, BFu, CWu, XLi, SWang, CZhang, Z Spiro ring compound as hepatitis C virus (HCV) inhibitor and uses thereof US Patent  US9416139 Publication Date 8/16/2016 
Target
Name:
Genome polyprotein [1973-2419]
Synonyms:
Non-structural protein 5A (NS5A) | POLG_HCVCO | RNA-directed RNA polymerase (NS5B)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48705.67
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
Q9WMX2[1973-2419]
Residue:
447
Sequence:
SGSWLRDVWDWICTVLTDFKTWLQSKLLPRLPGVPFFSCQRGYKGVWRGDGIMQTTCPCGAQITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFLVGLNQYLVGSQLPCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLKATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFEPLQAEEDEREVSVPAEILRRSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLSESTVSSALAELATKTFGSSESSAVDSGTATASPDQPSDDGDAGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCC
  
Inhibitor
Name:
BDBM241853
Synonyms:
US9416139, 31
Type:
Small organic molecule
Emp. Form.:
C54H63N9O6
Mol. Mass.:
934.1347
SMILES:
COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc(-c2ncc(c3CC4(CCCC4)Cc23)-c2ccc3nc([nH]c3c2)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)OC)C(C)C)c2ccccc12 |r|
Structure:
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