Reaction Details Report a problem with these data
Target
Sphingosine kinase 1
Ligand
BDBM241934
Substrate
n/a
Meas. Tech.
Kinase Assay
Temperature
310.15±n/a K
Ki
>100000±n/a nM
Comments
extracted
Citation
 Lynch, KR; Macdonald, TL; Mathews, TP; Kennedy, A; Kharel, Y Imidamide sphingosine kinase inhibitors US Patent  US9421177 Publication Date 8/23/2016 
Target
Name:
Sphingosine kinase 1
Synonyms:
SK1 | SPHK | SPHK1 | SPHK1_HUMAN | SPK | Sphingosine kinase 1 | Sphingosine kinase 1 (SPHK1) | Sphingosine kinase types 1 (SphK1)
Type:
Enzyme
Mol. Mass.:
42521.16
Organism:
Homo sapiens (Human)
Description:
Q9NYA1
Residue:
384
Sequence:
MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
  
Inhibitor
Name:
BDBM241934
Synonyms:
US9421177, VPC95127
Type:
Small organic molecule
Emp. Form.:
C20H31N3O2
Mol. Mass.:
345.479
SMILES:
CCCCCCCCc1ccc(cc1)C(=O)N1CCC[C@H]1\C(N)=N\O |r|
Structure:
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