Reaction Details Report a problem with these data
Target
Sphingosine kinase 2
Ligand
BDBM241904
Substrate
n/a
Meas. Tech.
Kinase Assay
Temperature
310.15±n/a K
Ki
23000±n/a nM
Comments
extracted
Citation
 Lynch, KR; Macdonald, TL; Mathews, TP; Kennedy, A; Kharel, Y Imidamide sphingosine kinase inhibitors US Patent  US9421177 Publication Date 8/23/2016 
Target
Name:
Sphingosine kinase 2
Synonyms:
SK 2 | SPHK2_MOUSE | SPK 2 | Sphingosine kinase 2 | Sphingosine kinase 2 (SPHK2) | Sphk2
Type:
Enzyme
Mol. Mass.:
65617.92
Organism:
Mus musculus (Mouse)
Description:
Q9JIA7
Residue:
617
Sequence:
MAPPPLLPVAASTPILHGEFGSYPANGPRFALTLTTQALHIQRLRPKPEARPRDGLVSLDEVSGCGTLQSRSPEDTAAYFCIYTYPRGRRGGRRRATRTFRADGATTYEENRAEAQRWATALTCLLRGVPLSGDQEITPELLPRKPRLLILVNPFGGRGLAWQRCMDHVVPMISEAGLSFNLIQTERQNHARELVQGLSLSEWEGIVTVSGDGLLYEVLNGLLDRPDWEDAVRMPIGVLPCGSGNALAGAVNHHGGFEQVVGVDLLLNCSLLLCRGGSHPLDLLSVTLASGSRCFSFLSVAWGFLSDVDIHSERFRALGSARFTLGAVLGLASLHTYRGRLSYLPATTEPALPIPGHSLPRAKSELVLAPAPAPAATHSPLHRSVSDLPLPLPQPALVSPGSPEPLPDLSLNGGGPELTGDWGGAGDAPLSPDPLLPSSPNALKTAQLSPIAEGPPEMPASSGFLPPTHSAPEASTWGPVDHLLPPLGSPLPQDWVTIEGEFVLMLGILPSHLCADLMAAPHARFDDGVVHLCWVRSGISRAALLRILLAMEHGNHFSLGCPHLGYAAARAFRLEPLTPRGLLTVDGELVEYGPIQAQVHPGLATLLTGPAGQKPQA
  
Inhibitor
Name:
BDBM241904
Synonyms:
US9421177, VPC96031
Type:
Small organic molecule
Emp. Form.:
C19H29N3O2
Mol. Mass.:
331.4525
SMILES:
CCCCCCCCc1ccc(cc1)C(=O)NC1(CC1)C(\N)=N\O
Structure:
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