Reaction Details Report a problem with these data
Target
Acid ceramidase
Ligand
BDBM50431262
Substrate
n/a
Meas. Tech.
Acid Ceramidase Activity Assay
pH
4.5±n/a
IC50
35±n/a nM
Comments
extracted
Citation
 Piomelli, D; Realini, N; Mor, M; Pagliuca, C; Pizzirani, D; Scarpelli, R; Bandiera, T Acid ceramidase inhibitors and their use as medicaments US Patent  US9428465 Publication Date 8/30/2016 
Target
Name:
Acid ceramidase
Synonyms:
ASAH | ASAH1 | ASAH1_HUMAN | Acid ceramidase | Acid ceramidase (AC)
Type:
Enzyme
Mol. Mass.:
44662.65
Organism:
Homo sapiens (Human)
Description:
Q13510
Residue:
395
Sequence:
MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
  
Inhibitor
Name:
BDBM50431262
Synonyms:
CHEMBL2333042 | US9428465, 5
Type:
Small organic molecule
Emp. Form.:
C11H16BrN3O3
Mol. Mass.:
318.167
SMILES:
CCCCCCNC(=O)n1cc(Br)c(=O)[nH]c1=O
Structure:
Search PDB for entries with ligand similarity: