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TargetBeta-secretase 2 (BACE2)
LigandBDBM242268
Substrate/Competitorn/a
Meas. Tech.HTRF FRET Assay
Ki 0.41±n/a nM
Citation Gilbert, EJCumming, JNStamford, AWYu, YScott, JDIserloh, UWang, LCaldwell, JP Tricyclic substituted thiadiazine dioxide compounds as BACE inhibitors, compositions and their use US Patent US9416129 Publication Date 8/16/2016
More Info.:Get all data from this article,  Assay Method
 
Beta-secretase 2 (BACE2)
Name:Beta-secretase 2 (BACE2)
Synonyms:ASP1 | Asp 1 | Aspartic-like protease 56 kDa | Aspartyl protease 1 | Beta secretase 2 | Beta-secretase 2 (BACE-2) | Beta-secretase 2 precursor | Beta-site APP-cleaving enzyme 2 | Down region aspartic protease | Memapsin-1 | Membrane-associated aspartic protease 1 | beta-Secretase (BACE-2)
Type:Enzyme
Mol. Mass.:56171.20
Organism:Homo sapiens (human)
Description:n/a
Residue:518
Sequence:
MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL
ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG
TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI
FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA
GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA
IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI
YLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFD
RAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCG
AILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM242268
NameBDBM242268
Synonyms:US9416129, 46
TypeSmall organic molecule
Emp. Form.C17H16ClN5O3S2
Mol. Mass.437.924
SMILESCN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)-c1ncon1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a