Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM242355
Substrate
n/a
Meas. Tech.
Kinase-Glo Assay
Temperature
298.15±n/a K
IC50
8±n/a nM
Comments
extracted
Citation
 Xu, YBrenning, BGKultgen, SGLiu, XSaunders, MHo, K Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors US Patent  US9416132 Publication Date 8/16/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM242355
Synonyms:
US9416132, 8-11
Type:
Small organic molecule
Emp. Form.:
C20H21F3N4O2
Mol. Mass.:
406.4015
SMILES:
CO[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:2.1,wD:5.8,(-9.3,2.86,;-7.96,3.63,;-6.63,2.86,;-5.25,3.6,;-3.91,2.83,;-3.91,1.29,;-5.25,.52,;-6.58,1.29,;-2.58,.52,;-1.25,1.29,;-1.25,2.83,;.09,3.6,;1.42,2.83,;2.89,3.31,;3.79,2.06,;2.89,.82,;3.28,-.67,;2.2,-1.76,;2.59,-3.25,;4.08,-3.65,;5.22,-2.57,;6.71,-2.97,;7.11,-4.46,;7.51,-5.94,;8.6,-4.06,;5.62,-4.86,;4.77,-1.07,;1.42,1.29,;.09,.52,)|
Structure:
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