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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50043687
Substrate
n/a
Meas. Tech.
Kinase-Glo Assay
Temperature
298.15±n/a K
IC50
378±n/a nM
Comments
extracted
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, M; Ho, K Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors US Patent  US9416132 Publication Date 8/16/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50043687
Synonyms:
CHEMBL3355547 | US9416132, 8-49
Type:
Small organic molecule
Emp. Form.:
C20H21F3N4O2
Mol. Mass.:
406.4015
SMILES:
CO[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1 |r,wU:2.1,wD:5.8,(37.44,-13.65,;38.78,-12.89,;40.11,-13.66,;41.44,-12.9,;42.77,-13.66,;42.77,-15.21,;41.44,-15.98,;40.11,-15.2,;44.1,-15.98,;45.44,-15.21,;45.44,-13.67,;46.77,-12.89,;48.09,-13.67,;49.56,-13.19,;50.47,-14.44,;49.56,-15.68,;50.32,-17.02,;49.53,-18.34,;50.29,-19.68,;51.83,-19.7,;52.61,-18.36,;54.15,-18.37,;54.91,-19.71,;56.45,-19.72,;54.13,-21.04,;55.59,-21.08,;51.85,-17.03,;48.09,-15.21,;46.77,-15.97,)|
Structure:
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