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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50043663
Substrate
n/a
Meas. Tech.
Kinase-Glo Assay
Temperature
298.15±n/a K
IC50
54±n/a nM
Comments
extracted
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, M; Ho, K Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors US Patent  US9416132 Publication Date 8/16/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50043663
Synonyms:
CHEMBL3355551 | US10392392, Example 8-55 | US10875864, EX. 8-55 | US9416132, 8-55
Type:
Small organic molecule
Emp. Form.:
C20H21F3N4O
Mol. Mass.:
390.4021
SMILES:
C[C@]1(O)CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(c3)C(F)(F)F)c2n1 |r,wU:1.1,wD:5.8,(32.77,-22.86,;33.55,-24.2,;32.05,-24.6,;34.89,-23.44,;36.21,-24.2,;36.21,-25.75,;34.89,-26.52,;33.55,-25.74,;37.55,-26.52,;38.88,-25.75,;38.88,-24.21,;40.21,-23.43,;41.54,-24.21,;43,-23.73,;43.91,-24.98,;43,-26.22,;43.76,-27.56,;42.97,-28.88,;43.73,-30.22,;45.27,-30.24,;46.05,-28.9,;45.29,-27.57,;47.59,-28.91,;48.35,-30.25,;48.37,-27.58,;49.13,-28.91,;41.54,-25.75,;40.21,-26.51,)|
Structure:
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