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Target
Egl nine homolog 1
Ligand
BDBM242569
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
pH
7.5±n/a
IC50
54±n/a nM
Comments
extracted
Citation
 Takayama, T; Shibata, T; Shiozawa, F; Kawabe, K; Shimizu, Y; Hamada, M; Hiratate, A; Takahashi, M; Ushiyama, F; Oi, T; Shirasaki, Y; Matsuda, D; Koizumi, C; Kato, S Partially saturated nitrogen-containing heterocyclic compound US Patent  US9422240 Publication Date 8/23/2016 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM242569
Synonyms:
US9422240, 1-385
Type:
Small organic molecule
Emp. Form.:
C20H20N4O6
Mol. Mass.:
412.396
SMILES:
Cc1ccc(Oc2cnc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cn2)cc1 |t:15|
Structure:
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