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Target
Bromodomain-containing protein 4 [44-168]
Ligand
BDBM242708
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
31±n/a nM
Citation
 Engelhardt, H; Gianni, D; Kessler, D; Reiser, U; Smethurst, C; Steffen, A Triazolopyridazine US Patent  US9422290 Publication Date 8/23/2016 
Target
Name:
Bromodomain-containing protein 4 [44-168]
Synonyms:
BET bromodomain 4(1) (BRD4(1)) | BRD4 | BRD4-BD1 protein (aa 44-168) | BRD4_HUMAN | Bromodomain protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 (BRD4) (aa 44-168) | Bromodomain-containing protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 bromodomain 1 (BRD4-BD1) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14866.49
Organism:
Homo sapiens (Human)
Description:
aa (44-168)
Residue:
125
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM242708
Synonyms:
US9422290, II-18
Type:
Small organic molecule
Emp. Form.:
C19H21N7O
Mol. Mass.:
363.4163
SMILES:
CC(C)Nc1cc(nn2c(C)nnc12)-c1cn(C)nc1Oc1ccccc1
Structure:
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