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Target
E3 ubiquitin-protein ligase XIAP [124-214,C202A,C213G]
Ligand
BDBM242806
Substrate
n/a
Meas. Tech.
TR-FRET Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
75±n/a nM
Comments
extracted
Citation
 Donnell, AF; Kester, R; Lou, Y; Anthony, J; Remiszewski, S 2-oxo-2,3,4,5-tetrahydro-1 H-benzo[B]diazepines and their use in the treatment of cancer US Patent  US9422331 Publication Date 8/23/2016 
Target
Name:
E3 ubiquitin-protein ligase XIAP [124-214,C202A,C213G]
Synonyms:
API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP (BIR2) | IAP3 | XIAP | XIAP_HUMAN
Type:
Enzyme
Mol. Mass.:
14676.71
Organism:
Artificial Organism
Description:
P98170[124-214,C202A,C213G]
Residue:
125
Sequence:
MRHHHHHHRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDFPNCFFVLGRAWSEHRRHRNLNIRSE
  
Inhibitor
Name:
BDBM242806
Synonyms:
US9422331, 28
Type:
Small organic molecule
Emp. Form.:
C31H35N5O5S
Mol. Mass.:
589.705
SMILES:
CCN[C@@H](C)C(=O)N[C@H]1[C@H](C)N(C(=O)CS(C)(=O)=O)c2cc(ccc2N(Cc2c(C)ccc3ccccc23)C1=O)C#N |r|
Structure:
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