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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM243086
Substrate
n/a
Meas. Tech.
5α-R1 Activity Assay
pH
7.5±n/a
IC50
9.0e+2± 2 nM
Comments
extracted
Citation
 Bratoeff, E; Sánchez, A; Arellano, Y; Heuze, Y; Soriano, J; Cabeza, M In vivo and in vitro effect of androstene derivatives as 5a-reductase type 1 enzyme inhibitors. J Enzyme Inhib Med Chem 28:1247-54 (2013) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
Enzyme
Mol. Mass.:
29472.80
Organism:
Homo sapiens (Human)
Description:
P18405
Residue:
259
Sequence:
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
  
Inhibitor
Name:
BDBM243086
Synonyms:
17-Chloro-16-formylandrost-5,16-diene-3β-yl-p-chlorobenzoate (9)
Type:
Small organic molecule
Emp. Form.:
C27H30Cl2O3
Mol. Mass.:
473.431
SMILES:
C[C@]12CCC3C(CC=C4C[C@H](CC[C@]34C)OC(=O)c3ccc(Cl)cc3)C1CC(C=O)=C2Cl |r,c:33,t:7|
Structure:
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