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Target
Genome polyprotein [1973-2419,L2003M]
Ligand
BDBM243449
Substrate
n/a
Meas. Tech.
Transient Replicon Assay
EC50
0.053±n/a nM
Citation
 Vandyck, K; Last, SJ; Houpis, IN; Raboisson, PJ Benzimidazole-imidazole derivatives US Patent  US9427428 Publication Date 8/30/2016 
Target
Name:
Genome polyprotein [1973-2419,L2003M]
Synonyms:
Non-structural protein 5A (NS5A)(L31M) | POLG_HCVCO | Serine protease NS5A (L31M)
Type:
Enzyme
Mol. Mass.:
48723.71
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
aa 1973-2419
Residue:
447
Sequence:
SGSWLRDVWDWICTVLTDFKTWLQSKLLPRMPGVPFFSCQRGYKGVWRGDGIMQTTCPCGAQITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFLVGLNQYLVGSQLPCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLKATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFEPLQAEEDEREVSVPAEILRRSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLSESTVSSALAELATKTFGSSESSAVDSGTATASPDQPSDDGDAGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCC
  
Inhibitor
Name:
BDBM243449
Synonyms:
US9427428, 13 | US9433609, 13
Type:
Small organic molecule
Emp. Form.:
C43H52N8O6
Mol. Mass.:
776.923
SMILES:
CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Structure:
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