Target
Genome polyprotein [1973-2419,L2003V]
Ligand
BDBM243446
Substrate
n/a
Meas. Tech.
Transient Replicon Assay
EC50
0.311±n/a nM
Citation
 Vandyck, KLast, SJHoupis, INRaboisson, PJ Benzimidazole-imidazole derivatives US Patent  US9427428 Publication Date 8/30/2016 
Target
Name:
Genome polyprotein [1973-2419,L2003V]
Synonyms:
Non-structural protein 5A (NS5A)(L31V) | POLG_HCVCO | Serine protease NS5A (L31V)
Type:
Enzyme
Mol. Mass.:
48691.64
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
aa 1973-2419
Residue:
447
Sequence:
SGSWLRDVWDWICTVLTDFKTWLQSKLLPRVPGVPFFSCQRGYKGVWRGDGIMQTTCPCGAQITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFLVGLNQYLVGSQLPCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLKATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFEPLQAEEDEREVSVPAEILRRSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLSESTVSSALAELATKTFGSSESSAVDSGTATASPDQPSDDGDAGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCC
  
Inhibitor
Name:
BDBM243446
Synonyms:
US9427428, 8 | US9433609, 8
Type:
Small organic molecule
Emp. Form.:
C44H54N8O6
Mol. Mass.:
790.9496
SMILES:
CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)CC |r|
Structure:
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