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Target
Genome polyprotein [1973-2419,Y2165H]
Ligand
BDBM243438
Substrate
n/a
Meas. Tech.
Transient Replicon Assay
EC50
0.167±n/a nM
Citation
 Vandyck, K; Last, SJ; Houpis, IN; Raboisson, PJ Benzimidazole-imidazole derivatives US Patent  US9427428 Publication Date 8/30/2016 
Target
Name:
Genome polyprotein [1973-2419,Y2165H]
Synonyms:
Non-structural protein 5A (NS5A)(Y93H) | POLG_HCVCO | Serine protease NS5A (Y93H)
Type:
Enzyme
Mol. Mass.:
48680.14
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
aa 1973-2419
Residue:
447
Sequence:
SGSWLRDVWDWICTVLTDFKTWLQSKLLPRLPGVPFFSCQRGYKGVWRGDGIMQTTCPCGAQITGHVKNGSMRIVGPRTCSNTWHGTFPINAHTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFLVGLNQYLVGSQLPCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLKATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFEPLQAEEDEREVSVPAEILRRSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLSESTVSSALAELATKTFGSSESSAVDSGTATASPDQPSDDGDAGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCC
  
Inhibitor
Name:
BDBM243438
Synonyms:
US9427428, 11
Type:
Small organic molecule
Emp. Form.:
C42H50N8O7
Mol. Mass.:
778.8958
SMILES:
CO[C@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@H](NC(=O)OC)C(C)C |r|
Structure:
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