Target
Genome polyprotein [2420-3010]
Ligand
BDBM243462
Substrate
n/a
Meas. Tech.
Primer-Dependent Transcription Assay
Temperature
298.15±n/a K
IC50
530±n/a nM
Comments
extracted
Citation
 Vendeville, SMRaboisson, PJLin, TTahri, AAmssoms, KI Macrocyclic indole derivatives useful as hepatitis C virus inhibitors US Patent  US9427440 Publication Date 8/30/2016 
Target
Name:
Genome polyprotein [2420-3010]
Synonyms:
POLG_HCVCO | RNA polymerase (NS5B) | RNA-directed RNA polymerase (NS5B)
Type:
Enzyme
Mol. Mass.:
65783.36
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
aa 2420-3010
Residue:
591
Sequence:
SMSYTWTGALITPCAAEETKLPINALSNSLLRHHNLVYATTSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSARSKFGYGAKDVRNLSSKAVNHIRSVWKDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPGQRVEFLVNAWKAKKCPMGFAYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAAAACRAAKLQDCTMLVCGDDLVVICESAGTQEDEASLRAFTEAMTRYSAPPGDPPKPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIQRLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVRTKLKLTPIPAASQLDLSSWFVAGYSGGDIYHSLSRARPRWFMWCLLLLSVGVGIYLLPNR
  
Inhibitor
Name:
BDBM243462
Synonyms:
US9427440, 3
Type:
Small organic molecule
Emp. Form.:
C32H40N4O6S
Mol. Mass.:
608.748
SMILES:
COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3C[C@@H](Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |r|
Structure:
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