Reaction Details Report a problem with these data
Target
Atypical chemokine receptor 3
Ligand
BDBM243830
Substrate
n/a
Meas. Tech.
In Vitro Assay
Temperature
310.15±n/a K
EC50
9±n/a nM
Comments
extracted
Citation
 Fretz, H; Gude, M; Guerry, P; Kimmerlin, T; Lehembre, F; Pfeifer, T; Valdenaire, A 1-[m-carboxamido(hetero)aryl-methyl]-heterocyclyl-carboxamide derivatives US Patent  US9428456 Publication Date 8/30/2016 
Target
Name:
Atypical chemokine receptor 3
Synonyms:
ACKR3 | ACKR3_HUMAN | C-X-C chemokine receptor type 7 | C-X-C chemokine receptor type 7 (CXCR7) | CMKOR1 | CXC-R7 | CXCR-7 | CXCR7 | Chemokine orphan receptor 1 | G-protein coupled receptor 159 | G-protein coupled receptor RDC1 homolog | GPR159 | RDC-1 | RDC1
Type:
Enzyme
Mol. Mass.:
41498.84
Organism:
Homo sapiens (Human)
Description:
P25106
Residue:
362
Sequence:
MDLHLFDYSEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQSTK
  
Inhibitor
Name:
BDBM243830
Synonyms:
US9428456, 2.033
Type:
Small organic molecule
Emp. Form.:
C29H30ClN3O2
Mol. Mass.:
488.02
SMILES:
Clc1ccc(cc1)C(=O)Nc1cccc(CN2CCC(CC2)C(=O)NC2Cc3ccccc3C2)c1
Structure:
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