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TargetAndrogen receptor (AR)
LigandBDBM245166
Substrate/Competitorn/a
Meas. Tech.Transactivation Assay
Temperature310.15±n/a K
IC50 330±n/a nM
Commentsextracted
Citation Nguyen, DKünzer, HFaus Gimenez, HBader, BKöhr, SFritsch, M N-[4-(quinolin-4-yloxy)cyclohexyl(methyl)](hetero)arylcarboxamides as androgen receptor antagonists, production and use thereof as medicinal products US Patent US9428460 Publication Date 8/30/2016
More Info.:Get all data from this article,  Assay Method
 
Androgen receptor (AR)
Name:Androgen receptor (AR)
Synonyms:Androgen receptor
Type:n/a
Mol. Mass.:98986.06
Organism:Homo sapiens (Human)
Description:Entry Version 159, Sequence Version 2 (P10275)
Residue:919
Sequence:
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQ
QQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSA
LECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLK
DILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELCKA
VSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAGKS
TEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQSR
DYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGP
GSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPY
GYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLE
TARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRND
CTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETTQKLT
VSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRM
YSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDR
IIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIIS
VQVPKILSGKVKPIYFHTQ
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  Blast E-value cutoff:
BDBM245166
NameBDBM245166
Synonyms:US9428460, 22
TypeSmall organic molecule
Emp. Form.C24H23N3O2
Mol. Mass.385.4583
SMILESO=C(NC[C@H]1CC[C@@H](CC1)Oc1ccnc2ccccc12)c1ccc(cc1)C#N |r,wU:7.10,wD:4.3,(2.67,4.62,;2.67,3.08,;1.33,2.31,;,3.08,;-1.33,2.31,;-2.67,3.08,;-4,2.31,;-4,.77,;-2.67,,;-1.33,.77,;-5.33,,;-5.33,-1.54,;-4,-2.31,;-4,-3.85,;-5.33,-4.62,;-6.67,-3.85,;-8,-4.62,;-9.34,-3.85,;-9.34,-2.31,;-8,-1.54,;-6.67,-2.31,;4,2.31,;4,.77,;5.33,,;6.72,.74,;6.67,2.31,;5.33,3.08,;8.05,-.03,;9.38,-.8,)|
Structure
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