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Target
Genome polyprotein [192-746]
Ligand
BDBM245441
Substrate
n/a
Meas. Tech.
Reporter Assay
Temperature
310.15±n/a K
EC50
29±n/a nM
Comments
extracted
Citation
 Ding, Q; Jiang, N; Weikert, RJ Antiviral compounds US Patent  US9428469 Publication Date 8/30/2016 
Target
Name:
Genome polyprotein [192-746]
Synonyms:
Envelope glycoprotein E1 and E2 | POLG_HCVCO
Type:
Enzyme
Mol. Mass.:
61000.13
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
aa 192-746
Residue:
555
Sequence:
YEVRNVSGVYHVTNDCSNASIVYEAADMIMHTPGCVPCVRENNSSRCWVALTPTLAARNASVPTTTIRRHVDLLVGAAALCSAMYVGDLCGSVFLVAQLFTFSPRRHETVQDCNCSIYPGHVTGHRMAWDMMMNWSPTAALVVSQLLRIPQAVVDMVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGGTYVTGGTMAKNTLGITSLFSPGSSQKIQLVNTNGSWHINRTALNCNDSLNTGFLAALFYVHKFNSSGCPERMASCSPIDAFAQGWGPITYNESHSSDQRPYCWHYAPRPCGIVPAAQVCGPVYCFTPSPVVVGTTDRFGVPTYSWGENETDVLLLNNTRPPQGNWFGCTWMNSTGFTKTCGGPPCNIGGIGNKTLTCPTDCFRKHPEATYTKCGSGPWLTPRCLVHYPYRLWHYPCTVNFTIFKVRMYVGGVEHRLEAACNWTRGERCNLEDRDRSELSPLLLSTTEWQVLPCSFTTLPALSTGLIHLHQNVVDVQYLYGIGSAVVSFAIKWEYVLLLFLLLADARVCACLWMMLLIAQAEA
  
Inhibitor
Name:
BDBM245441
Synonyms:
US9428469, 23
Type:
Small organic molecule
Emp. Form.:
C21H20Cl2N6O2
Mol. Mass.:
459.329
SMILES:
CC(C)(C)OC(=O)c1ccc(CNc2nc(Nc3cc(Cl)c(C#N)c(Cl)c3)n[nH]2)cc1
Structure:
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