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Target
Bromodomain-containing protein 4 [44-168]
Ligand
BDBM245786
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
333±n/a nM
Citation
 Engelhardt, H Triazolopyrazine US Patent  US9428513 Publication Date 8/30/2016 
Target
Name:
Bromodomain-containing protein 4 [44-168]
Synonyms:
BET bromodomain 4(1) (BRD4(1)) | BRD4 | BRD4-BD1 protein (aa 44-168) | BRD4_HUMAN | Bromodomain protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 (BRD4) (aa 44-168) | Bromodomain-containing protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 bromodomain 1 (BRD4-BD1) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14866.49
Organism:
Homo sapiens (Human)
Description:
aa (44-168)
Residue:
125
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM245786
Synonyms:
US9428513, I-2
Type:
Small organic molecule
Emp. Form.:
C23H31N9O2
Mol. Mass.:
465.5513
SMILES:
COC[C@@H](C)n1c(nc2cnc(cc12)N1CCOCC1)-c1cn2c(C)nnc2c(NC(C)C)n1 |r|
Structure:
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