Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [352-457]
Ligand
BDBM245896
Substrate
n/a
Meas. Tech.
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay
pH
6±n/a
Temperature
298.15±n/a K
Ki
67.5±n/a nM
Comments
extracted
Citation
 Bogdan, A; Kati, WM; McDaniel, KF; Park, CH; Sheppard, GS; Wang, L Bromodomain inhibitors US Patent  US9428514 Publication Date 8/30/2016 
Target
Name:
Bromodomain-containing protein 4 [352-457]
Synonyms:
BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(aa 352-457) | Bromodomain-containing protein 4 (BRD4-BD2) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12432.37
Organism:
Homo sapiens (Human)
Description:
BDII: amino acid E352-M457
Residue:
106
Sequence:
EQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKM
  
Inhibitor
Name:
BDBM245896
Synonyms:
US9428514, 84
Type:
Small organic molecule
Emp. Form.:
C25H22F2N4O4
Mol. Mass.:
480.4634
SMILES:
CCOc1cc(=O)n(C)cc1-c1cc(NC(=O)Cn2cccn2)ccc1Oc1ccc(F)cc1F
Structure:
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