Reaction Details Report a problem with these data
Target
Genome polyprotein [1973-2419,L2000T]
Ligand
BDBM245924
Substrate
n/a
Meas. Tech.
Transient Transfection Assay
EC50
0.037±n/a nM
Citation
 Vandyck, K; Last, SJ; Houpis, IN; Raboisson, PJ Benzimidazole-imidazole derivatives US Patent  US9433609 Publication Date 9/6/2016 
Target
Name:
Genome polyprotein [1973-2419,L2000T]
Synonyms:
Non-structural protein 5A (NS5A)(L28T) | POLG_HCVCO | Serine protease NS5A (L28T)
Type:
Enzyme
Mol. Mass.:
48693.61
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
aa 1973-2419
Residue:
447
Sequence:
SGSWLRDVWDWICTVLTDFKTWLQSKLTPRLPGVPFFSCQRGYKGVWRGDGIMQTTCPCGAQITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFLVGLNQYLVGSQLPCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLKATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFEPLQAEEDEREVSVPAEILRRSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLSESTVSSALAELATKTFGSSESSAVDSGTATASPDQPSDDGDAGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCC
  
Inhibitor
Name:
BDBM245924
Synonyms:
US9433609, 17
Type:
Small organic molecule
Emp. Form.:
C43H52N8O7
Mol. Mass.:
792.9224
SMILES:
CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC |r|
Structure:
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