Reaction Details Report a problem with these data
Target
Genome polyprotein [1973-2419,L2003F]
Ligand
BDBM243443
Substrate
n/a
Meas. Tech.
Transient Transfection Assay
EC50
0.032±n/a nM
Citation
 Vandyck, K; Last, SJ; Houpis, IN; Raboisson, PJ Benzimidazole-imidazole derivatives US Patent  US9433609 Publication Date 9/6/2016 
Target
Name:
Genome polyprotein [1973-2419,L2003F]
Synonyms:
Non-structural protein 5A (NS5A)(L31F) | POLG_HCVCO | Serine protease NS5A (L31F)
Type:
Enzyme
Mol. Mass.:
48739.68
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
aa 1973-2419
Residue:
447
Sequence:
SGSWLRDVWDWICTVLTDFKTWLQSKLLPRFPGVPFFSCQRGYKGVWRGDGIMQTTCPCGAQITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFLVGLNQYLVGSQLPCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLKATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFEPLQAEEDEREVSVPAEILRRSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLSESTVSSALAELATKTFGSSESSAVDSGTATASPDQPSDDGDAGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCC
  
Inhibitor
Name:
BDBM243443
Synonyms:
US9427428, 3 | US9433609, 3
Type:
Small organic molecule
Emp. Form.:
C42H50N8O6
Mol. Mass.:
762.8964
SMILES:
COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Structure:
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