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Target
Genome polyprotein [1973-2419,Y2165C]
Ligand
BDBM243439
Substrate
n/a
Meas. Tech.
Transient Transfection Assay
EC50
<0.013±n/a nM
Citation
 Vandyck, K; Last, SJ; Houpis, IN; Raboisson, PJ Benzimidazole-imidazole derivatives US Patent  US9433609 Publication Date 9/6/2016 
Target
Name:
Genome polyprotein [1973-2419,Y2165C]
Synonyms:
Non-structural protein 5A (NS5A)(Y93C) | POLG_HCVCO | Serine protease NS5A (Y93C)
Type:
Enzyme
Mol. Mass.:
48645.64
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
aa 1973-2419
Residue:
447
Sequence:
SGSWLRDVWDWICTVLTDFKTWLQSKLLPRLPGVPFFSCQRGYKGVWRGDGIMQTTCPCGAQITGHVKNGSMRIVGPRTCSNTWHGTFPINACTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFLVGLNQYLVGSQLPCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLKATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFEPLQAEEDEREVSVPAEILRRSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLSESTVSSALAELATKTFGSSESSAVDSGTATASPDQPSDDGDAGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCC
  
Inhibitor
Name:
BDBM243439
Synonyms:
US9427428, 9 | US9433609, 9
Type:
Small organic molecule
Emp. Form.:
C42H50N8O7
Mol. Mass.:
778.8958
SMILES:
CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Structure:
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