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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM246303
Substrate
n/a
Meas. Tech.
[125I]DOI Radioligand Binding Assay.
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
36±n/a nM
Comments
extracted
Citation
 Xiong, Y; Cherrier, MC; Choi, JS; Dosa, PI; Smith, BM; Strah-Pleynet, S; Ullman, B; Teegarden, B Pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto US Patent  US9434692 Publication Date 9/6/2016 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM246303
Synonyms:
US9434692, 24
Type:
Small organic molecule
Emp. Form.:
C17H20ClFN4O
Mol. Mass.:
350.818
SMILES:
Cn1cc(Cl)c(n1)C(=O)N1CCN(CCc2ccccc2F)CC1
Structure:
Search PDB for entries with ligand similarity: