Reaction Details Report a problem with these data
Target
Short transient receptor potential channel 5
Ligand
BDBM246466
Substrate
n/a
Meas. Tech.
Patch Clamp Assay
pH
7.2±n/a
IC50
<1±n/a nM
Comments
extracted
Citation
 Chenard, BL; Gallaschun, RJ Thieno- and furo[2,3-d]pyrimidine-2,4[1H,3H]-dione derivatives US Patent  US9447114 Publication Date 9/20/2016 
Target
Name:
Short transient receptor potential channel 5
Synonyms:
TRP5 | TRPC5 | TRPC5_HUMAN | Transient receptor protein 5 (TRPC5)
Type:
Enzyme
Mol. Mass.:
111421.47
Organism:
Homo sapiens (Human)
Description:
Q9UL62
Residue:
973
Sequence:
MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRSFSTSSTELSQRDDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGPSLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEINLSEVELGEVQGAAQSSECPLACSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTRL
  
Inhibitor
Name:
BDBM246466
Synonyms:
US9447114, 27
Type:
Small organic molecule
Emp. Form.:
C23H20Cl2N2O4
Mol. Mass.:
459.322
SMILES:
Cn1c2oc(c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O)-c1cccc(Cl)c1
Structure:
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