Reaction Details Report a problem with these data
Target
Pancreatic triacylglycerol lipase
Ligand
BDBM246487
Substrate
BDBM246504
Meas. Tech.
In Vitro Pancreatic Lipase Assay
pH
7.4±0
Temperature
310.15±0 K
Ki
6.79e+3± 4.0e+2 nM
IC50
3.232e+4± 1.91e+3 nM
Citation
 Yang, MH; Chin, YW; Yoon, KD; Kim, J Phenolic compounds with pancreatic lipase inhibitory activity from Korean yam (Dioscorea opposita). J Enzyme Inhib Med Chem 29:1-6 (2014) [PubMed]  Article 
Target
Name:
Pancreatic triacylglycerol lipase
Synonyms:
LIPP_PIG | PL | PNLIP | PTL | Pancreatic lipase | Pancreatic triacylglycerol lipase
Type:
Enzyme
Mol. Mass.:
50080.69
Organism:
Sus scrofa (Pig)
Description:
P00591
Residue:
450
Sequence:
SEVCFPRLGCFSDDAPWAGIVQRPLKILPWSPKDVDTRFLLYTNQNQNNYQELVADPSTITNSNFRMDRKTRFIIHGFIDKGEEDWLSNICKNLFKVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEVLKSSLGYSPSNVHVIGHSLGSHAAGEAGRRTNGTIERITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDAAPIIPNLGFGMSQTVGHLDFFPNGGKQMPGCQKNILSQIVDIDGIWEGTRDFVACNHLRSYKYYADSILNPDGFAGFPCDSYNVFTANKCFPCPSEGCPQMGHYADRFPGKTNGVSQVFYLNTGDASNFARWRYKVSVTLSGKKVTGHILVSLFGNEGNSRQYEIYKGTLQPDNTHSDEFDSDVEVGDLQKVKFIWYNNNVINPTLPRVGASKITVERNDGKVYDFCSQETVREEVLLTLNPC
  
Inhibitor
Name:
BDBM246487
Synonyms:
Batatasin III (4)
Type:
Small organic molecule
Emp. Form.:
C15H16O3
Mol. Mass.:
244.2857
SMILES:
COc1cc(O)cc(CCc2cccc(O)c2)c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM246504
Synonyms:
4-Methylumbelliferyl oleate (4-MU oleate)
Type:
Small organic molecule
Emp. Form.:
C28H40O4
Mol. Mass.:
440.6148
SMILES:
CCCCCCCC\C=C/CCCCCCCC(=O)Oc1ccc2c(C)cc(=O)oc2c1
Structure:
Search PDB for entries with ligand similarity: