Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM246539
Substrate
n/a
Meas. Tech.
In Vitro Inhibition Assay
IC50
11140±n/a nM
Citation
 Sonmez, F; Bilen, C; Sumersan, S; Gencer, N; Isik, S; Arslan, O; Kucukislamoglu, M In vitro inhibition effect and structure-activity relationships of some saccharin derivatives on erythrocyte carbonic anhydrase I and II. J Enzyme Inhib Med Chem 29:118-23 (2014) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM246539
Synonyms:
Saccharin derivative, 6m
Type:
Small organic molecule
Emp. Form.:
C15H13N3O3S2
Mol. Mass.:
347.412
SMILES:
Cc1ccc(NC(=S)Nc2ccc3C(=O)NS(=O)(=O)c3c2)cc1
Structure:
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