Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50163863
Substrate
n/a
Meas. Tech.
Thermal Shift Assay (TSA)
pH
7±n/a
Kd
8.3±n/a nM
Comments
extracted
Citation
 Zubriene, A; Capkauskaite, E; Gylyte, J; Ki?onaite, M; Tumkevicius, S; Matulis, D Benzenesulfonamides with benzimidazole moieties as inhibitors of carbonic anhydrases I, II, VII, XII and XIII. J Enzyme Inhib Med Chem 29:124-31 (2014) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50163863
Synonyms:
4-(1H-benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide (2a) | CHEMBL3798446 | carbonic anhydrase (CA) inhibitors, benzenesulphonamide ligand, 2
Type:
Small organic molecule
Emp. Form.:
C15H12ClN3O3S
Mol. Mass.:
349.792
SMILES:
NS(=O)(=O)c1ccc(cc1Cl)C(=O)Cn1cnc2ccccc12
Structure:
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