Reaction Details Report a problem with these data
Target
Carbonic anhydrase 13
Ligand
BDBM246561
Substrate
n/a
Meas. Tech.
Thermal Shift Assay (TSA)
pH
7±n/a
Kd
5.56±n/a nM
Comments
extracted
Citation
 Zubriene, A; Capkauskaite, E; Gylyte, J; Ki?onaite, M; Tumkevicius, S; Matulis, D Benzenesulfonamides with benzimidazole moieties as inhibitors of carbonic anhydrases I, II, VII, XII and XIII. J Enzyme Inhib Med Chem 29:124-31 (2014) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 13
Synonyms:
CA13 | CAH13_HUMAN | Carbonic anhydrase | Carbonic anhydrase 13 (CA XIII) | Carbonic anhydrase XIII (CA XIII)
Type:
Enzyme
Mol. Mass.:
29445.78
Organism:
Homo sapiens (Human)
Description:
Q8N1Q1
Residue:
262
Sequence:
MSRLSWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKIISNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRASFH
  
Inhibitor
Name:
BDBM246561
Synonyms:
2-Chloro-4-[(2-propyl-1H-benzimidazol-1-yl)acetyl]benzenesulfonamide (2f)
Type:
Small organic molecule
Emp. Form.:
C18H18ClN3O3S
Mol. Mass.:
391.872
SMILES:
CCCc1nc2ccccc2n1CC(=O)c1ccc(c(Cl)c1)S(N)(=O)=O
Structure:
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