Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit alpha-2/delta
Ligand
BDBM247435
Substrate
n/a
Meas. Tech.
[3H]-Gabapentin Binding Assay
Temperature
298.15±n/a K
IC50
4.1±n/a nM
Comments
extracted
Citation
 Otsubo, N; Okazaki, S; Tsukumo, Y; Iida, K; Nakoji, M Pyrimidodiazepinone compound US Patent  US9453021 Publication Date 9/27/2016 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-2/delta
Synonyms:
Gama-aminobutyric acid (GABA) alpha 2 delta
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Gamma-aminobutyric acid receptor subunit alpha-2
Synonyms:
GABA A Alpha2Beta2Gamma2 | GABA A alpha2 | GABA A receptor alpha-2/beta-2/gamma-2 | GABA receptor alpha-2 subunit | GABA(A) receptor subunit alpha-2 | GBRA2_RAT | Gabra-2 | Gabra2 | Gamma-aminobutyric acid receptor subunit alpha-2
Type:
Enzyme
Mol. Mass.:
51195.57
Organism:
Rattus norvegicus (Rat)
Description:
P23576
Residue:
451
Sequence:
MRTKLSTCNVWFPLLVLLVWNPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNSMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNPSDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKGSVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNREPVLGVSP
  
Component 2
Name:
Gamma-aminobutyric acid receptor subunit delta
Synonyms:
GABA(A) receptor subunit delta | GBRD_RAT | Gabrd
Type:
Enzyme
Mol. Mass.:
50571.23
Organism:
Rattus norvegicus (Rat)
Description:
P18506
Residue:
449
Sequence:
MDVLGWLLLPLLLLCTQPHHGARAMNDIGDYVGSNLEISWLPNLDGLMEGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSENQEQIHGLDRLQLAQFTITSYRFTTELMNFKSAGQFPRLSLHFQLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKRKAKVKVTKPRAEMDVRNAIVLFSLSAAGVSQELAISRRQGRVPGNLMGSYRSVEVEAKKEGGSRPGGPGGIRSRLKPIDADTIDIYARAVFPAAFAAVNIIYWAAYTM
  
Inhibitor
Name:
BDBM247435
Synonyms:
US9453021, 68
Type:
Small organic molecule
Emp. Form.:
C19H20N8O2
Mol. Mass.:
392.4145
SMILES:
CNc1ncc2c(n1)N1CCC[C@H]1CN(c1cncc3c1ncn(C)c3=O)C2=O
Structure:
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