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Target
Casein kinase II subunit alpha/beta
Ligand
BDBM248077
Substrate
BDBM248093
Meas. Tech.
In Vitro Kinase Assay
pH
7.5±0
Temperature
303.15±0 K
IC50
1.95e+4±n/a nM
Citation
 Chekanov, MO; Ostrynska, OV; Synyugin, AR; Bdzhola, VG; Yarmoluk, SM Design, synthesis and evaluation of 2-phenylisothiazolidin-3-one-1,1-dioxides as a new class of human protein kinase CK2 inhibitors. J Enzyme Inhib Med Chem 29:338-43 (2014) [PubMed]  Article 
Target
Name:
Casein kinase II subunit alpha/beta
Synonyms:
Casein kinase 2 (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha alpha beta beta | Complex of catalytic (CK2α) and non-catalytic (CK2β) subunits
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 989485
Components:
This complex has 2 components.
Component 1
Name:
Casein kinase II subunit alpha
Synonyms:
CK II | CK2 | CK2- alpha | CK2A1 | CSK21_HUMAN | CSNK2A1 | Casein kinase 2 | Casein kinase II (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha (CK2 alpha) | Casein kinase II subunit alpha (CK2A1) | Casein kinase II subunit alpha (CK2a I174A) | Casein kinase II subunit alpha (CK2a V66A) | Casein kinase II subunit alpha (CK2a dm V66I174AA) | Casein kinase II subunit alpha (CK2a)
Type:
Enzyme
Mol. Mass.:
45151.12
Organism:
Homo sapiens (Human)
Description:
P68400
Residue:
391
Sequence:
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
  
Component 2
Name:
Casein kinase II subunit beta
Synonyms:
CK II beta | CSK2B_RAT | Casein kinase II beta | Casein kinase II subunit beta | Ck2n | Csnk2b | Phosvitin
Type:
PROTEIN
Mol. Mass.:
24937.13
Organism:
Rattus norvegicus
Description:
EBI_10969
Residue:
215
Sequence:
MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDEELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPANQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR
  
Inhibitor
Name:
BDBM248077
Synonyms:
2-hydroxy-4-{[4-(4-methyl-1,1-dioxido-3-oxoisothiazolidin-2-yl)benzoyl]amino}benzoic acid (27)
Type:
Small organic molecule
Emp. Form.:
C18H16N2O7S
Mol. Mass.:
404.394
SMILES:
CC1CS(=O)(=O)N(C1=O)c1ccc(cc1)C(=O)Nc1ccc(C(O)=O)c(O)c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM248093
Synonyms:
RRRDDDSDDD
Type:
Peptide
Emp. Form.:
C45H73N19O24
Mol. Mass.:
1264.174
SMILES:
N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(O)=O |r|
Structure:
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